{"id":361,"date":"2019-08-21T23:05:14","date_gmt":"2019-08-21T21:05:14","guid":{"rendered":"https:\/\/www.labvet.cz\/blog\/?p=361"},"modified":"2025-03-07T20:39:11","modified_gmt":"2025-03-07T19:39:11","slug":"ctli-zlaty-standard-pro-diagnostiku-epi","status":"publish","type":"post","link":"https:\/\/labvet.cz\/blog\/ctli-zlaty-standard-pro-diagnostiku-epi\/","title":{"rendered":"cTLi – zlat\u00fd standard pro diagnostiku EPI"},"content":{"rendered":"\n

Repetitio mater studiorum – proto nejd\u0159\u00edve trochu teorie. Test na cTLI m\u011b\u0159\u00ed v s\u00e9ru trypsin a trypsinogen. Trypsinogen je syntetizov\u00e1n pouze ve slinivce a a\u017e v tenk\u00e9m st\u0159ev\u011b je p\u0159em\u011bn\u011bn na aktivn\u00ed proteolytick\u00fd enzym trypsin. Norm\u00e1ln\u00ed je v krvi mal\u00e9 mno\u017estv\u00ed obou t\u011bchto enzym\u016f (respektive proenzymu a enzymu). Jejich m\u011b\u0159en\u00ed se proto vyu\u017e\u00edv\u00e1 k diagnostice EPI a \u010d\u00e1ste\u010dn\u011b i pankreatitidy.<\/p>\n\n\n\n

Na vy\u0161et\u0159en\u00ed by zv\u00ed\u0159e m\u011blo b\u00fdt na la\u010dno, p\u0159\u00edpadnou or\u00e1ln\u00ed suplementaci tr\u00e1vic\u00edch enzym\u016f nen\u00ed pot\u0159eba vysazovat, s\u00e9rov\u00e9 TLI toti\u017e neovliv\u0148uje. Krev je nutno nabrat do zkumavky k z\u00edsk\u00e1n\u00ed s\u00e9ra, z plazmy vy\u0161et\u0159en\u00ed nen\u00ed mo\u017en\u00e9. <\/p>\n\n\n\n

\"\"<\/a><\/figure>\n\n\n\n

N\u00edzk\u00e9 hladiny TLI sv\u011bd\u010d\u00ed pro EPI, je zde vysok\u00e1 specifita i senzitivita testu. Vysok\u00e9 hladiny mohou sv\u011bd\u010dit o akutn\u00edm z\u00e1n\u011btu slinivky psa, je ale zapot\u0159eb\u00ed z\u00e1rove\u0148 zkontrolovat funkci ledvin, kter\u00e9 trypsinogen vylu\u010duj\u00ed. Vinou jejich nedostate\u010dn\u00e9 funkce tak m\u016f\u017ee rovn\u011b\u017e doj\u00edt ke zv\u00fd\u0161en\u00e9 hladin\u011b TLI. Jestli\u017ee m\u00e1me podez\u0159en\u00ed na pankreatitidu u psa, je vzorky zapot\u0159eb\u00ed odebrat co nejd\u0159\u00edve po vzniku p\u0159\u00edznak\u016f, proto\u017ee s progreduj\u00edc\u00edm onemocn\u011bn\u00edm hladina TLI kles\u00e1. Zde je sensitivita pouze 33-36% a specifita 65-90%. Vhodn\u011bj\u0161\u00ed je proto prov\u00e9st test na PLI.<\/p>\n\n\n\n

Klinick\u00e1 EPI se projevuje, a\u017e kdy\u017e je sekre\u010dn\u00ed kapacita slinivky redukov\u00e1na pod 10-15 % norm\u00e1lu.<\/p>\n\n\n\n

P\u0159i podez\u0159en\u00ed, kter\u00e9 se nepotvrd\u00ed laboratorn\u011b, se doporu\u010duje pacienta hl\u00eddat a test opakovat po 3 – 6 m\u011bs\u00edc\u00edch. <\/p>\n\n\n\n

\"\"<\/a><\/figure>\n","protected":false},"excerpt":{"rendered":"

Repetitio mater studiorum – proto nejd\u0159\u00edve trochu teorie. Test na cTLI m\u011b\u0159\u00ed v s\u00e9ru trypsin a trypsinogen. Trypsinogen je syntetizov\u00e1n pouze ve slinivce a a\u017e v tenk\u00e9m st\u0159ev\u011b je p\u0159em\u011bn\u011bn na aktivn\u00ed proteolytick\u00fd enzym trypsin. Norm\u00e1ln\u00ed je v krvi mal\u00e9 mno\u017estv\u00ed obou t\u011bchto enzym\u016f (respektive proenzymu a enzymu). Jejich m\u011b\u0159en\u00ed se proto vyu\u017e\u00edv\u00e1 k diagnostice … <\/p>\n

Pokra\u010dovat ve \u010dten\u00ed „cTLi – zlat\u00fd standard pro diagnostiku EPI“<\/span><\/a><\/p>\n","protected":false},"author":4,"featured_media":881,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_seopress_robots_primary_cat":"none","_seopress_titles_title":"cTLi - zlat\u00fd standard pro diagnostiku EPI | Labvet.cz","_seopress_titles_desc":"Test na cTLi m\u011b\u0159\u00ed v s\u00e9ru trypsin a trypsinogen. Pou\u017e\u00edv\u00e1 se k diagnostice poruch exokrinn\u00edho pankreatu a chronick\u00e9 pankreatitidy ps\u016f s poruchou zevn\u00ed sekrece.","_seopress_robots_index":"","footnotes":""},"categories":[6],"tags":[189,192,190,191],"class_list":["post-361","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-www-labvet-cz-blog-vetlaborator","tag-ctli","tag-pankreatitida-u-psa","tag-tli-u-psa","tag-zanet-slinivky-u-psa"],"yoast_head":"\ncTLi - zlat\u00fd standard pro diagnostiku EPI - Labvet blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/labvet.cz\/blog\/ctli-zlaty-standard-pro-diagnostiku-epi\/\" \/>\n<meta property=\"og:locale\" content=\"cs_CZ\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"cTLi - zlat\u00fd standard pro diagnostiku EPI - Labvet blog\" \/>\n<meta property=\"og:description\" content=\"Repetitio mater studiorum – proto nejd\u0159\u00edve trochu teorie. Test na cTLI m\u011b\u0159\u00ed v s\u00e9ru trypsin a trypsinogen. Trypsinogen je syntetizov\u00e1n pouze ve slinivce a a\u017e v tenk\u00e9m st\u0159ev\u011b je p\u0159em\u011bn\u011bn na aktivn\u00ed proteolytick\u00fd enzym trypsin. Norm\u00e1ln\u00ed je v krvi mal\u00e9 mno\u017estv\u00ed obou t\u011bchto enzym\u016f (respektive proenzymu a enzymu). 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Trypsinogen je syntetizov\u00e1n pouze ve slinivce a a\u017e v tenk\u00e9m st\u0159ev\u011b je p\u0159em\u011bn\u011bn na aktivn\u00ed proteolytick\u00fd enzym trypsin. Norm\u00e1ln\u00ed je v krvi mal\u00e9 mno\u017estv\u00ed obou t\u011bchto enzym\u016f (respektive proenzymu a enzymu). Jejich m\u011b\u0159en\u00ed se proto vyu\u017e\u00edv\u00e1 k diagnostice … Pokra\u010dovat ve \u010dten\u00ed \"cTLi – zlat\u00fd standard pro diagnostiku EPI\"","og_url":"https:\/\/labvet.cz\/blog\/ctli-zlaty-standard-pro-diagnostiku-epi\/","og_site_name":"Labvet blog","article_publisher":"https:\/\/www.facebook.com\/Labvet.cz","article_published_time":"2019-08-21T21:05:14+00:00","article_modified_time":"2025-03-07T19:39:11+00:00","og_image":[{"width":810,"height":435,"url":"https:\/\/labvet.cz\/blog\/wp-content\/uploads\/2019\/08\/Kopie-n\u00e1vrhu-Kopie-n\u00e1vrhu-Kopie-n\u00e1vrhu-N\u00e1vrh-bez-n\u00e1zvu.jpg","type":"image\/jpeg"}],"author":"Hana Prausov\u00e1","twitter_card":"summary_large_image","twitter_misc":{"Napsal(a)":"Hana Prausov\u00e1","Odhadovan\u00e1 doba \u010dten\u00ed":"1 minuta"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/labvet.cz\/blog\/ctli-zlaty-standard-pro-diagnostiku-epi\/#article","isPartOf":{"@id":"https:\/\/labvet.cz\/blog\/ctli-zlaty-standard-pro-diagnostiku-epi\/"},"author":{"name":"Hana Prausov\u00e1","@id":"https:\/\/labvet.cz\/blog\/#\/schema\/person\/2d735d5f05fa2f6b256e9f5cd30e663b"},"headline":"cTLi – zlat\u00fd standard pro diagnostiku EPI","datePublished":"2019-08-21T21:05:14+00:00","dateModified":"2025-03-07T19:39:11+00:00","mainEntityOfPage":{"@id":"https:\/\/labvet.cz\/blog\/ctli-zlaty-standard-pro-diagnostiku-epi\/"},"wordCount":283,"commentCount":0,"publisher":{"@id":"https:\/\/labvet.cz\/blog\/#organization"},"image":{"@id":"https:\/\/labvet.cz\/blog\/ctli-zlaty-standard-pro-diagnostiku-epi\/#primaryimage"},"thumbnailUrl":"https:\/\/labvet.cz\/blog\/wp-content\/uploads\/2019\/08\/Kopie-n\u00e1vrhu-Kopie-n\u00e1vrhu-Kopie-n\u00e1vrhu-N\u00e1vrh-bez-n\u00e1zvu.jpg","keywords":["ctli","pankreatitida u psa","tli u psa","z\u00e1n\u011bt slinivky u psa"],"articleSection":["Laborato\u0159 pro veterin\u00e1\u0159e"],"inLanguage":"cs","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/labvet.cz\/blog\/ctli-zlaty-standard-pro-diagnostiku-epi\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/labvet.cz\/blog\/ctli-zlaty-standard-pro-diagnostiku-epi\/","url":"https:\/\/labvet.cz\/blog\/ctli-zlaty-standard-pro-diagnostiku-epi\/","name":"cTLi - 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V laborato\u0159\u00edch pracuji od r. 1993. Od r. 1997 pracovala deset let ve St\u00e1tn\u00edm veterin\u00e1rn\u00edm \u00fastavu v Liberci v n\u00e1rodn\u00ed referen\u010dn\u00ed laborato\u0159i pro vzteklinu. Od r. 2003 jako vedouc\u00ed laborato\u0159e. Od r. 2008 p\u016fsob\u00edm v laborato\u0159\u00ed Labvetu a sou\u010dasn\u011b v Liberci vykon\u00e1v\u00e1m klinickou praxi. V\u011bnuji se p\u0159edev\u0161\u00edm dermatologii, alergologii, bakteriologii, parazitologii, mykologii.","sameAs":["http:\/\/www.labvet.cz"],"url":"https:\/\/labvet.cz\/blog\/author\/hanka\/"}]}},"_links":{"self":[{"href":"https:\/\/labvet.cz\/blog\/wp-json\/wp\/v2\/posts\/361","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labvet.cz\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/labvet.cz\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/labvet.cz\/blog\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/labvet.cz\/blog\/wp-json\/wp\/v2\/comments?post=361"}],"version-history":[{"count":7,"href":"https:\/\/labvet.cz\/blog\/wp-json\/wp\/v2\/posts\/361\/revisions"}],"predecessor-version":[{"id":4583,"href":"https:\/\/labvet.cz\/blog\/wp-json\/wp\/v2\/posts\/361\/revisions\/4583"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/labvet.cz\/blog\/wp-json\/wp\/v2\/media\/881"}],"wp:attachment":[{"href":"https:\/\/labvet.cz\/blog\/wp-json\/wp\/v2\/media?parent=361"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/labvet.cz\/blog\/wp-json\/wp\/v2\/categories?post=361"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/labvet.cz\/blog\/wp-json\/wp\/v2\/tags?post=361"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}